Osteopathic Family Physician
Volume 1, Issue 1 , Pages 9-11 , July 2009

Latent Autoimmune Diabetes of the Adult (LADA): a case report of a misunderstood form of diabetes

  • Jay McDougal IV, M.S.

      Affiliations

    • Department of Family Medicine, Ohio University College of Osteopathic Medicine, Athens, Ohio
    • Corresponding Author InformationCorresponding author. Jay McDougal, OMS IV, 3420 Market Street, Stockport, OH 43787
    • ,
  • Jay H. Shubrook Jr., DO, FACOFP

      Affiliations

    • Cornwell Center for Diabetes and Cardiovascular Disease, Athens, Ohio

References 

  1. Niskanen LK, Tuomi T, Karjalainen J, et al. GAD antibodies in NIDDM (Ten-year follow-up from the diagnosis). Diabetes Care. 1995;12:1557–1565
  2. Zimmet PZ. The pathogenesis and prevention of diabetes in adults (Genes, autoimmunity, and demography). Diabetes Care. 1995;7:1050–1064
  3. Harris MI. Prevalence of adult-onset IDDM in the U.S. population. Diabetes Care. 1994;11:1337–1340
  4. LinksStenström G, Gottsäter A, Bakhtadze E, et al. Latent autoimmune diabetes in adults: definition, prevalence, beta-cell function, and treatment. Diabetes. 2005;2(suppl):S68–S72
  5. Carlsson A, Sundkvist G, Groop L, et al. Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA). J Clin Endocrinol Metab. 2000;1:76–80
  6. Groop LC. Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis. Diabetes. 1986;2:237–241
  7. Fourlanos S, Perry C, Stein MS, et al. A clinical screening tool identifies autoimmune diabetes in adults. Diabetes Care. 2006;29:970–975
  8. Leslie RD, Williams R, Pozzilli P. Type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow. J Clin Endocrinol Metab. 2006;91:1654–1659
  9. Kobayashi T, Tanaka S, Okubo M, et al. Unique epitopes of glutamic acid decarboxylase autoantibodies in slowly progressive type 1 diabetes. J Clin Endocrinol Metab. 2003;88:4768–4775
  10. Falorni A, Gambelunghe G, Forini F, et al. Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus. J Clin Endocrinol Metab. 2000;1:309–316
  11. Maruyama T, Tanaka S, Shimada A, et al. Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus. J Clin Endocrinol Metab. 2008;6:2115–2121
  12. Rosário PW, Reis JS, Amim R, et al. Comparison of clinical and laboratory characteristics between adult-onset type 1 diabetes and latent autoimmune diabetes in adults. Diabetes Care. 2005;7:1803–1804

PII: S1877-573X(09)00003-3

doi: 10.1016/j.osfp.2009.04.002

Osteopathic Family Physician
Volume 1, Issue 1 , Pages 9-11 , July 2009

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